Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A

The low-density lipoprotein receptor–related protein 1 (LRP1) is an endocytic and cell signaling transmembrane protein. Endothelial LRP1 clears proteinaceous toxins at the blood–brain barrier (BBB), regulates angiogenesis, and is increasingly reduced in Alzheimer’s disease associated with BBB breakd...

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Detalles Bibliográficos
Autores principales: Nikolakopoulou, Angeliki Maria, Wang, Yaoming, Ma, Qingyi, Sagare, Abhay P., Montagne, Axel, Huuskonen, Mikko T., Rege, Sanket V., Kisler, Kassandra, Dai, Zhonghua, Körbelin, Jakob, Herz, Joachim, Zhao, Zhen, Zlokovic, Berislav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863706/
https://www.ncbi.nlm.nih.gov/pubmed/33533918
http://dx.doi.org/10.1084/jem.20202207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863706/
https://www.ncbi.nlm.nih.gov/pubmed/33533918
http://dx.doi.org/10.1084/jem.20202207

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