SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions

SARS-CoV-2 was first reported from China. Within three months, it evolved to 10 additional subtypes. Two evolved subtypes (A2 and A2a) carry a non-synonymous Spike protein mutation (D614G). We conducted phylodynamic analysis of over 70,000 SARS-CoV-2 coronaviruses worldwide, sequenced until July2020...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Chandrika, Das, Chitrarpita, Ghosh, Arnab, Singh, Animesh K., Mukherjee, Souvik, Majumder, Partha P., Basu, Analabha, Biswas, Nidhan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863758/
https://www.ncbi.nlm.nih.gov/pubmed/33556558
http://dx.doi.org/10.1016/j.meegid.2021.104760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863758/
https://www.ncbi.nlm.nih.gov/pubmed/33556558
http://dx.doi.org/10.1016/j.meegid.2021.104760

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