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Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells

Elevated levels of fasting insulin release and insufficient glucose-stimulated insulin secretion (GSIS) are hallmarks of diabetes. Studies have established cross-talk between integrin signaling and insulin activity, but more details of how integrin-dependent signaling impacts the pathophysiology of...

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Detalles Bibliográficos
Autores principales: Arous, Caroline, Mizgier, Maria Luisa, Rickenbach, Katharina, Pinget, Michel, Bouzakri, Karim, Wehrle-Haller, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864053/
https://www.ncbi.nlm.nih.gov/pubmed/32934005
http://dx.doi.org/10.1074/jbc.RA120.012957