Coupled intra- and interdomain dynamics support domain cross-talk in Pin1

The functional mechanisms of multidomain proteins often exploit interdomain interactions, or “cross-talk.” An example is human Pin1, an essential mitotic regulator consisting of a Trp–Trp (WW) domain flexibly tethered to a peptidyl-prolyl isomerase (PPIase) domain, resulting in interdomain interacti...

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Detalles Bibliográficos
Autores principales: Zhang, Meiling, Frederick, Thomas E., VanPelt, Jamie, Case, David A., Peng, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864058/
https://www.ncbi.nlm.nih.gov/pubmed/32963105
http://dx.doi.org/10.1074/jbc.RA120.015849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864058/
https://www.ncbi.nlm.nih.gov/pubmed/32963105
http://dx.doi.org/10.1074/jbc.RA120.015849

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