Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling

The glucagon receptor (GCGR) activated by the peptide hormone glucagon is a seven-transmembrane G protein–coupled receptor (GPCR) that regulates blood glucose levels. Ubiquitination influences trafficking and signaling of many GPCRs, but its characterization for the GCGR is lacking. Using endocytic...

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Detalles Bibliográficos
Autores principales: Kaur, Suneet, Chen, Yuqing, Shenoy, Sudha K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864061/
https://www.ncbi.nlm.nih.gov/pubmed/32967969
http://dx.doi.org/10.1074/jbc.RA120.014532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864061/
https://www.ncbi.nlm.nih.gov/pubmed/32967969
http://dx.doi.org/10.1074/jbc.RA120.014532

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