Cargando…

Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition

Large regions in tumor tissues, particularly pancreatic cancer, are hypoxic and nutrient-deprived because of unregulated cell growth and insufficient vascular supply. Certain cancer cells, such as those inside a tumor, can tolerate these severe conditions and survive for prolonged periods. We hypoth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Onodera, Takefumi, Momose, Isao, Adachi, Hayamitsu, Yamazaki, Yohko, Sawa, Ryuichi, Ohba, Shun-ichi, Kawada, Manabu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864064/ https://www.ncbi.nlm.nih.gov/pubmed/32978257 http://dx.doi.org/10.1074/jbc.RA120.013893

Ejemplares similares

Deoxynortryptoquivaline: A unique antiprostate cancer agent
por: YAMAZAKI, YOHKO, et al.
Publicado: (2023)

Vibrio japonicus sp. nov., a novel member of the Nereis clade in the genus Vibrio isolated from the coast of Japan
por: Doi, Hiroyasu, et al.
Publicado: (2017)

New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells
por: Atsumi, Sonoko, et al.
Publicado: (2016)

Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors
por: Momose, Isao, et al.
Publicado: (2014)

Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer
por: Sakamoto, Shuichi, et al.
Publicado: (2020)

Foregut Exclusion Disrupts Intestinal Glucose Sensing and Alters Portal Nutrient and Hormonal Milieu
por: Pal, Atanu, et al.
Publicado: (2015)

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways
por: Xiao, Fei, et al.
Publicado: (2011)

Three cytosolic NAD-malate dehydrogenase isoforms of Arabidopsis thaliana: on the crossroad between energy fluxes and redox signaling
por: Liszka, Aleksandra, et al.
Publicado: (2020)

Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo
por: Lam, Carol K.L., et al.
Publicado: (2011)

Novel autophagy inducers lentztrehaloses A, B and C
por: Wada, Shun-ichi, et al.
Publicado: (2015)

S6K1 in the Central Nervous System Regulates Energy Expenditure via MC4R/CRH Pathways in Response to Deprivation of an Essential Amino Acid
por: Xia, Tingting, et al.
Publicado: (2012)

Global Identification of Genes Related to Nutrient Deficiency in Intervertebral Disc Cells in an Experimental Nutrient Deprivation Model
por: Sudo, Hideki, et al.
Publicado: (2013)

Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism
por: Gurley, Jami M., et al.
Publicado: (2016)

GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice
por: Tocchetti, Carlo G., et al.
Publicado: (2012)

Anti-Metastatic Activity of an Anti-EGFR Monoclonal Antibody against Metastatic Colorectal Cancer with KRAS p.G13D Mutation
por: Ohishi, Tomokazu, et al.
Publicado: (2020)

Evaluation of sodium butyrate and nutrient concentration for broiler chickens
por: Mallo, J.J., et al.
Publicado: (2021)

Impacts of phytase and coccidial vaccine on growth performance, nutrient digestibility, bone development, and intestinal gene expression of broilers fed a nutrient reduced diet
por: Shi, Hanyi, et al.
Publicado: (2023)

Educational Case: Nutrient Deprivation and Anemia
por: Nickens, Caitlin, et al.
Publicado: (2019)

Chestnut tannins in broiler diets: performance, nutrient digestibility, and meat quality
por: Buyse, Kobe, et al.
Publicado: (2021)

Influence of Trans-anethole on the nutrient digestibility and intestinal barrier function in broilers
por: Yu, Caiyun, et al.
Publicado: (2021)

Research Note: The effect of sequential displacement of dietary dextrose with myo-inositol on broiler chicken growth performance, bone characteristics, ileal nutrient digestibility, and total tract nutrient retention
por: Cowieson, A.J., et al.
Publicado: (2020)

Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance
por: Kawano, Yoshinaga, et al.
Publicado: (2012)

The impact of deoxynivalenol, fumonisins, and their combination on performance, nutrient, and energy digestibility in broiler chickens
por: Liu, J.D., et al.
Publicado: (2019)

Starving for nutrients: anorexia during infection with parasites in broilers is affected by diet composition
por: Taylor, James, et al.
Publicado: (2021)

Octopamine connects nutrient cues to lipid metabolism upon nutrient deprivation
por: Tao, Jun, et al.
Publicado: (2016)

From menu to mouth: the decay pathway of nutrient intake from planned menu to consumed and characteristics of residents in an aged care facility with greater nutrient decay rates: a cross-sectional study
por: Nanayakkara, Wathsala Sripali, et al.
Publicado: (2019)

The effects of xylo-oligosaccharides on regulating growth performance, nutrient utilization, gene expression of tight junctions, nutrient transporters, and cecal short chain fatty acids profile in Eimeria-challenged broiler chickens
por: Lin, Yang, et al.
Publicado: (2022)

Research Note: Corn energy and nutrient utilization by broilers as affected by geographic areas and carbohydrases
por: Stefanello, Catarina, et al.
Publicado: (2022)

The effect of different wheat varieties and exogenous xylanase on bird performance and utilization of energy and nutrients
por: Whiting, I.M., et al.
Publicado: (2023)

Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling
por: KAWATANI, MAKOTO, et al.
Publicado: (2023)

Generation and evaluation of a chimeric antibody against coxsackievirus and adenovirus receptor for cancer therapy
por: Sakamoto, Shuichi, et al.
Publicado: (2019)

Evaluation of the nutrient content of yogurts: a comprehensive survey of yogurt products in the major UK supermarkets
por: Moore, J Bernadette, et al.
Publicado: (2018)

Effect of almond hulls as an alternative ingredient on broiler performance, nutrient digestibility, and cecal microbiota diversity
por: Wang, J., et al.
Publicado: (2020)

Effect of almond hulls on the performance, egg quality, nutrient digestibility, and body composition of laying hens
por: Wang, J., et al.
Publicado: (2021)

Impact of fermentable fiber, xylo-oligosaccharides and xylanase on laying hen productive performance and nutrient utilization
por: Morgan, N.K., et al.
Publicado: (2022)

Effects of supplemental L-methionine on growth performance and redox status of turkey poults compared with the use of DL-methionine()
por: Park, I, et al.
Publicado: (2018)

Hydrogen peroxide–induced oxidative stress impairs redox status and damages aerobic metabolism of breast muscle in broilers
por: Chen, Zuodong, et al.
Publicado: (2020)

Can the relationship between ethnicity and obesity-related behaviours among school-aged children be explained by deprivation? A cross-sectional study
por: Falconer, Catherine L, et al.
Publicado: (2014)

Effects of exogenous proteases without or with carbohydrases on nutrient digestibility and disappearance of non-starch polysaccharides in broiler chickens
por: Olukosi, O. A., et al.
Publicado: (2015)

Influence of coccidiosis vaccination on nutrient utilization of corn, soybean meal, and distillers dried grains with solubles in broilers
por: Gautier, A.E., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7h8094h55endfcn5lkrhe1e51m