α(2)-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester

Proteins in the α-macroglobulin (αM) superfamily use thiol esters to form covalent conjugation products upon their proteolytic activation. αM protease inhibitors use theirs to conjugate proteases and preferentially react with primary amines (e.g. on lysine side chains), whereas those of αM complemen...

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Detalles Bibliográficos
Autores principales: Harwood, Seandean Lykke, Nielsen, Nadia Sukusu, Jensen, Kathrine Tejlgård, Nielsen, Peter Kresten, Thøgersen, Ida B., Enghild, Jan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864068/
https://www.ncbi.nlm.nih.gov/pubmed/32978260
http://dx.doi.org/10.1074/jbc.RA120.015694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864068/
https://www.ncbi.nlm.nih.gov/pubmed/32978260
http://dx.doi.org/10.1074/jbc.RA120.015694

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