ERAD deficiency promotes mitochondrial dysfunction and transcriptional rewiring in human hepatic cells

Mitochondrial dysfunction is associated with a variety of human diseases including neurodegeneration, diabetes, nonalcohol fatty liver disease (NAFLD), and cancer, but its underlying causes are incompletely understood. Using the human hepatic cell line HepG2 as a model, we show here that endoplasmic...

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Detalles Bibliográficos
Autores principales: Liu, Qingqing, Yang, Xiaoqin, Long, Guangyu, Hu, Yabing, Gu, Zhenglong, Boisclair, Yves R., Long, Qiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864069/
https://www.ncbi.nlm.nih.gov/pubmed/32978261
http://dx.doi.org/10.1074/jbc.RA120.013987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864069/
https://www.ncbi.nlm.nih.gov/pubmed/32978261
http://dx.doi.org/10.1074/jbc.RA120.013987

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