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Conformational Landscape of Cytochrome P450 Reductase Interactions

Oxidative reactions catalyzed by Cytochrome P450 enzymes (CYPs), which constitute the most relevant group of drug-metabolizing enzymes, are enabled by their redox partner Cytochrome P450 reductase (CPR). Both proteins are anchored to the membrane of the endoplasmic reticulum and the CPR undergoes a...

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Detalles Bibliográficos
Autores principales: Sellner, Manuel, Fischer, André, Don, Charleen G., Smieško, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864194/
https://www.ncbi.nlm.nih.gov/pubmed/33498551
http://dx.doi.org/10.3390/ijms22031023