Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as pancreatic islets. Here, we investigated contributions of regulatory programs active during pancreatic development to T2D risk. Generation of chromatin maps from developmenta...

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Detalles Bibliográficos
Autores principales: Geusz, Ryan J, Wang, Allen, Chiou, Joshua, Lancman, Joseph J, Wetton, Nichole, Kefalopoulou, Samy, Wang, Jinzhao, Qiu, Yunjiang, Yan, Jian, Aylward, Anthony, Ren, Bing, Dong, P Duc Si, Gaulton, Kyle J, Sander, Maike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864636/
https://www.ncbi.nlm.nih.gov/pubmed/33544077
http://dx.doi.org/10.7554/eLife.59067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864636/
https://www.ncbi.nlm.nih.gov/pubmed/33544077
http://dx.doi.org/10.7554/eLife.59067

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