A multi-omics approach to Epstein-Barr virus immortalization of B-cells reveals EBNA1 chromatin pioneering activities targeting nucleotide metabolism

Epstein-Barr virus (EBV) immortalizes resting B-lymphocytes through a highly orchestrated reprogramming of host chromatin structure, transcription and metabolism. Here, we use a multi-omics-based approach to investigate these underlying mechanisms. ATAC-seq analysis of cellular chromatin showed that...

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Detalles Bibliográficos
Autores principales: Lamontagne, R. Jason, Soldan, Samantha S., Su, Chenhe, Wiedmer, Andreas, Won, Kyoung Jae, Lu, Fang, Goldman, Aaron R., Wickramasinghe, Jayamanna, Tang, Hsin-Yao, Speicher, David W., Showe, Louise, Kossenkov, Andrew V., Lieberman, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864721/
https://www.ncbi.nlm.nih.gov/pubmed/33497421
http://dx.doi.org/10.1371/journal.ppat.1009208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864721/
https://www.ncbi.nlm.nih.gov/pubmed/33497421
http://dx.doi.org/10.1371/journal.ppat.1009208

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