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Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes
AIMS/HYPOTHESIS: We hypothesised that human beta cells are structurally and functional polarised with respect to the islet capillaries. We set out to test this using confocal microscopy to map the 3D spatial arrangement of key proteins and live-cell imaging to determine the distribution of insulin g...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864831/ https://www.ncbi.nlm.nih.gov/pubmed/33399909 http://dx.doi.org/10.1007/s00125-020-05345-8 |