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Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes

AIMS/HYPOTHESIS: We hypothesised that human beta cells are structurally and functional polarised with respect to the islet capillaries. We set out to test this using confocal microscopy to map the 3D spatial arrangement of key proteins and live-cell imaging to determine the distribution of insulin g...

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Detalles Bibliográficos
Autores principales:	Cottle, Louise, Gan, Wan Jun, Gilroy, Ian, Samra, Jaswinder S., Gill, Anthony J., Loudovaris, Thomas, Thomas, Helen E., Hawthorne, Wayne J., Kebede, Melkam A., Thorn, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864831/ https://www.ncbi.nlm.nih.gov/pubmed/33399909 http://dx.doi.org/10.1007/s00125-020-05345-8

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