4-hydroxytamoxifen does not deteriorate cardiac function in cardiomyocyte-specific MerCreMer transgenic mice

Conditional, cell-type-specific transgenic mouse lines are of high value in cardiovascular research. A standard tool for cardiomyocyte-restricted DNA editing is the αMHC-MerCreMer/loxP system. However, there is an ongoing debate on the occurrence of cardiac side effects caused by unspecific Cre acti...

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Detalles Bibliográficos
Autores principales: Heinen, Andre, Gödecke, Stefanie, Flögel, Ulrich, Miklos, Dominika, Bottermann, Katharina, Spychala, André, Gödecke, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864833/
https://www.ncbi.nlm.nih.gov/pubmed/33544211
http://dx.doi.org/10.1007/s00395-020-00841-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864833/
https://www.ncbi.nlm.nih.gov/pubmed/33544211
http://dx.doi.org/10.1007/s00395-020-00841-9

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