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Adenosine A(2A) receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice
In fragile X syndrome (FXS) the lack of the fragile X mental retardation protein (FMRP) leads to exacerbated signaling through the metabotropic glutamate receptors 5 (mGlu5Rs). The adenosine A(2A) receptors (A(2A)Rs), modulators of neuronal damage, could play a role in FXS. A synaptic colocalization...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864914/ https://www.ncbi.nlm.nih.gov/pubmed/33547274 http://dx.doi.org/10.1038/s41398-021-01238-5 |