Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via a core FADD:Caspase-8 complex and its regulatory partners, such as the cell death inhibitor c-FLIP. Here, using electro...

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Detalles Bibliográficos
Autores principales: Fox, Joanna L., Hughes, Michelle A., Meng, Xin, Sarnowska, Nikola A., Powley, Ian R., Jukes-Jones, Rebekah, Dinsdale, David, Ragan, Timothy J., Fairall, Louise, Schwabe, John W. R., Morone, Nobuhiro, Cain, Kelvin, MacFarlane, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864959/
https://www.ncbi.nlm.nih.gov/pubmed/33547302
http://dx.doi.org/10.1038/s41467-020-20806-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864959/
https://www.ncbi.nlm.nih.gov/pubmed/33547302
http://dx.doi.org/10.1038/s41467-020-20806-9

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