Replication-independent instability of Friedreich’s ataxia GAA repeats during chronological aging

Nearly 50 hereditary diseases result from the inheritance of abnormally long repetitive DNA microsatellites. While it was originally believed that the size of inherited repeats is the key factor in disease development, it has become clear that somatic instability of these repeats throughout an indiv...

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Detalles Bibliográficos
Autores principales: Neil, Alexander J., Hisey, Julia A., Quasem, Ishtiaque, McGinty, Ryan J., Hitczenko, Marcin, Khristich, Alexandra N., Mirkin, Sergei M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865128/
https://www.ncbi.nlm.nih.gov/pubmed/33495349
http://dx.doi.org/10.1073/pnas.2013080118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865128/
https://www.ncbi.nlm.nih.gov/pubmed/33495349
http://dx.doi.org/10.1073/pnas.2013080118

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