KMU-1170, a Novel Multi-Protein Kinase Inhibitor, Suppresses Inflammatory Signal Transduction in THP-1 Cells and Human Osteoarthritic Fibroblast-Like Synoviocytes by Suppressing Activation of NF-κB and NLRP3 Inflammasome Signaling Pathway

Protein kinases regulate protein phosphorylation, which are involved in fundamental cellular processes such as inflammatory response. In this study, we discovered a novel multi-protein kinase inhibitor, KMU-1170, a derivative of indolin-2-one, and investigated the mechanisms of its inflammation-inhi...

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Detalles Bibliográficos
Autores principales: Baek, Hye Suk, Hong, Victor Sukbong, Kim, Sang Hyon, Lee, Jinho, Kim, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865241/
https://www.ncbi.nlm.nih.gov/pubmed/33530480
http://dx.doi.org/10.3390/ijms22031194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865241/
https://www.ncbi.nlm.nih.gov/pubmed/33530480
http://dx.doi.org/10.3390/ijms22031194

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