Cargando…
Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration
This paper reports the electrospinning fabrication of flexible nanostructured tubular scaffolds, based on fish gelatin (FG) and nanodiamond nanoparticles (NDs), and their cytocompatibility with murine neural stem cells. The effects of both nanofiller and protein concentration on the scaffold morphol...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865256/ https://www.ncbi.nlm.nih.gov/pubmed/33514051 http://dx.doi.org/10.3390/polym13030407 |
_version_ | 1783647803380072448 |
---|---|
author | Olăreț, Elena Drăgușin, Diana-Maria Serafim, Andrada Lungu, Adriana Șelaru, Aida Dobranici, Alexandra Dinescu, Sorina Costache, Marieta Boerașu, Iulian Vasile, Bogdan Ștefan Steinmüller-Nethl, Doris Iovu, Horia Stancu, Izabela-Cristina |
author_facet | Olăreț, Elena Drăgușin, Diana-Maria Serafim, Andrada Lungu, Adriana Șelaru, Aida Dobranici, Alexandra Dinescu, Sorina Costache, Marieta Boerașu, Iulian Vasile, Bogdan Ștefan Steinmüller-Nethl, Doris Iovu, Horia Stancu, Izabela-Cristina |
author_sort | Olăreț, Elena |
collection | PubMed |
description | This paper reports the electrospinning fabrication of flexible nanostructured tubular scaffolds, based on fish gelatin (FG) and nanodiamond nanoparticles (NDs), and their cytocompatibility with murine neural stem cells. The effects of both nanofiller and protein concentration on the scaffold morphology, aqueous affinity, size modification at rehydration, and degradation are assessed. Our findings indicate that nanostructuring with low amounts of NDs may modify the fiber properties, including a certain regional parallel orientation of fiber segments. NE-4C cells form dense clusters that strongly adhere to the surface of FG50-based scaffolds, while also increasing FG concentration and adding NDs favor cellular infiltration into the flexible fibrous FG70_NDs nanocomposite. This research illustrates the potential of nanostructured NDs-FG fibers as scaffolds for nerve repair and regeneration. We also emphasize the importance of further understanding the effect of the nanofiller-protein interphase on the microstructure and properties of electrospun fibers and on cell-interactivity. |
format | Online Article Text |
id | pubmed-7865256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78652562021-02-07 Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration Olăreț, Elena Drăgușin, Diana-Maria Serafim, Andrada Lungu, Adriana Șelaru, Aida Dobranici, Alexandra Dinescu, Sorina Costache, Marieta Boerașu, Iulian Vasile, Bogdan Ștefan Steinmüller-Nethl, Doris Iovu, Horia Stancu, Izabela-Cristina Polymers (Basel) Article This paper reports the electrospinning fabrication of flexible nanostructured tubular scaffolds, based on fish gelatin (FG) and nanodiamond nanoparticles (NDs), and their cytocompatibility with murine neural stem cells. The effects of both nanofiller and protein concentration on the scaffold morphology, aqueous affinity, size modification at rehydration, and degradation are assessed. Our findings indicate that nanostructuring with low amounts of NDs may modify the fiber properties, including a certain regional parallel orientation of fiber segments. NE-4C cells form dense clusters that strongly adhere to the surface of FG50-based scaffolds, while also increasing FG concentration and adding NDs favor cellular infiltration into the flexible fibrous FG70_NDs nanocomposite. This research illustrates the potential of nanostructured NDs-FG fibers as scaffolds for nerve repair and regeneration. We also emphasize the importance of further understanding the effect of the nanofiller-protein interphase on the microstructure and properties of electrospun fibers and on cell-interactivity. MDPI 2021-01-27 /pmc/articles/PMC7865256/ /pubmed/33514051 http://dx.doi.org/10.3390/polym13030407 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Olăreț, Elena Drăgușin, Diana-Maria Serafim, Andrada Lungu, Adriana Șelaru, Aida Dobranici, Alexandra Dinescu, Sorina Costache, Marieta Boerașu, Iulian Vasile, Bogdan Ștefan Steinmüller-Nethl, Doris Iovu, Horia Stancu, Izabela-Cristina Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration |
title | Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration |
title_full | Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration |
title_fullStr | Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration |
title_full_unstemmed | Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration |
title_short | Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration |
title_sort | electrospinning fabrication and cytocompatibility investigation of nanodiamond particles-gelatin fibrous tubular scaffolds for nerve regeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865256/ https://www.ncbi.nlm.nih.gov/pubmed/33514051 http://dx.doi.org/10.3390/polym13030407 |
work_keys_str_mv | AT olaretelena electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT dragusindianamaria electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT serafimandrada electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT lunguadriana electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT selaruaida electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT dobranicialexandra electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT dinescusorina electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT costachemarieta electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT boerasuiulian electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT vasilebogdanstefan electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT steinmullernethldoris electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT iovuhoria electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration AT stancuizabelacristina electrospinningfabricationandcytocompatibilityinvestigationofnanodiamondparticlesgelatinfibroustubularscaffoldsfornerveregeneration |