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Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration

This paper reports the electrospinning fabrication of flexible nanostructured tubular scaffolds, based on fish gelatin (FG) and nanodiamond nanoparticles (NDs), and their cytocompatibility with murine neural stem cells. The effects of both nanofiller and protein concentration on the scaffold morphol...

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Autores principales: Olăreț, Elena, Drăgușin, Diana-Maria, Serafim, Andrada, Lungu, Adriana, Șelaru, Aida, Dobranici, Alexandra, Dinescu, Sorina, Costache, Marieta, Boerașu, Iulian, Vasile, Bogdan Ștefan, Steinmüller-Nethl, Doris, Iovu, Horia, Stancu, Izabela-Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865256/
https://www.ncbi.nlm.nih.gov/pubmed/33514051
http://dx.doi.org/10.3390/polym13030407
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author Olăreț, Elena
Drăgușin, Diana-Maria
Serafim, Andrada
Lungu, Adriana
Șelaru, Aida
Dobranici, Alexandra
Dinescu, Sorina
Costache, Marieta
Boerașu, Iulian
Vasile, Bogdan Ștefan
Steinmüller-Nethl, Doris
Iovu, Horia
Stancu, Izabela-Cristina
author_facet Olăreț, Elena
Drăgușin, Diana-Maria
Serafim, Andrada
Lungu, Adriana
Șelaru, Aida
Dobranici, Alexandra
Dinescu, Sorina
Costache, Marieta
Boerașu, Iulian
Vasile, Bogdan Ștefan
Steinmüller-Nethl, Doris
Iovu, Horia
Stancu, Izabela-Cristina
author_sort Olăreț, Elena
collection PubMed
description This paper reports the electrospinning fabrication of flexible nanostructured tubular scaffolds, based on fish gelatin (FG) and nanodiamond nanoparticles (NDs), and their cytocompatibility with murine neural stem cells. The effects of both nanofiller and protein concentration on the scaffold morphology, aqueous affinity, size modification at rehydration, and degradation are assessed. Our findings indicate that nanostructuring with low amounts of NDs may modify the fiber properties, including a certain regional parallel orientation of fiber segments. NE-4C cells form dense clusters that strongly adhere to the surface of FG50-based scaffolds, while also increasing FG concentration and adding NDs favor cellular infiltration into the flexible fibrous FG70_NDs nanocomposite. This research illustrates the potential of nanostructured NDs-FG fibers as scaffolds for nerve repair and regeneration. We also emphasize the importance of further understanding the effect of the nanofiller-protein interphase on the microstructure and properties of electrospun fibers and on cell-interactivity.
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spelling pubmed-78652562021-02-07 Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration Olăreț, Elena Drăgușin, Diana-Maria Serafim, Andrada Lungu, Adriana Șelaru, Aida Dobranici, Alexandra Dinescu, Sorina Costache, Marieta Boerașu, Iulian Vasile, Bogdan Ștefan Steinmüller-Nethl, Doris Iovu, Horia Stancu, Izabela-Cristina Polymers (Basel) Article This paper reports the electrospinning fabrication of flexible nanostructured tubular scaffolds, based on fish gelatin (FG) and nanodiamond nanoparticles (NDs), and their cytocompatibility with murine neural stem cells. The effects of both nanofiller and protein concentration on the scaffold morphology, aqueous affinity, size modification at rehydration, and degradation are assessed. Our findings indicate that nanostructuring with low amounts of NDs may modify the fiber properties, including a certain regional parallel orientation of fiber segments. NE-4C cells form dense clusters that strongly adhere to the surface of FG50-based scaffolds, while also increasing FG concentration and adding NDs favor cellular infiltration into the flexible fibrous FG70_NDs nanocomposite. This research illustrates the potential of nanostructured NDs-FG fibers as scaffolds for nerve repair and regeneration. We also emphasize the importance of further understanding the effect of the nanofiller-protein interphase on the microstructure and properties of electrospun fibers and on cell-interactivity. MDPI 2021-01-27 /pmc/articles/PMC7865256/ /pubmed/33514051 http://dx.doi.org/10.3390/polym13030407 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Olăreț, Elena
Drăgușin, Diana-Maria
Serafim, Andrada
Lungu, Adriana
Șelaru, Aida
Dobranici, Alexandra
Dinescu, Sorina
Costache, Marieta
Boerașu, Iulian
Vasile, Bogdan Ștefan
Steinmüller-Nethl, Doris
Iovu, Horia
Stancu, Izabela-Cristina
Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration
title Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration
title_full Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration
title_fullStr Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration
title_full_unstemmed Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration
title_short Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration
title_sort electrospinning fabrication and cytocompatibility investigation of nanodiamond particles-gelatin fibrous tubular scaffolds for nerve regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865256/
https://www.ncbi.nlm.nih.gov/pubmed/33514051
http://dx.doi.org/10.3390/polym13030407
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