Cargando…

Pseudopeptide Amyloid Aggregation Inhibitors: In Silico, Single Molecule and Cell Viability Studies

Neurodegeneration in Alzheimer’s disease (AD) is defined by pathology featuring amyloid-β (Aβ) deposition in the brain. Aβ monomers themselves are generally considered to be nontoxic, but misfold into β-sheets and aggregate to form neurotoxic oligomers. One suggested strategy to treat AD is to preve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Robinson, Morgan, Lou, Jennifer, Mehrazma, Banafsheh, Rauk, Arvi, Beazely, Michael, Leonenko, Zoya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865305/ https://www.ncbi.nlm.nih.gov/pubmed/33494369 http://dx.doi.org/10.3390/ijms22031051

Ejemplares similares

d-Amino Acid Pseudopeptides as Potential Amyloid-Beta Aggregation Inhibitors
por: Mehrazma, Banafsheh, et al.
Publicado: (2018)

Effect of Metals on Kinetic Pathways of Amyloid-β Aggregation
por: Hane, Francis, et al.
Publicado: (2014)

On the Involvement of Copper Binding to the N-Terminus of the Amyloid Beta Peptide of Alzheimer's Disease: A Computational Study on Model Systems
por: Azimi, Samira, et al.
Publicado: (2011)

Orbital interaction theory of organic chemistry
por: Rauk, Arvi 1942-
Publicado: (2001)

Orbital interaction theory of organic chemistry
por: Rauk, Arvi 1942-
Publicado: (1994)

Cu(2+) Affects Amyloid-β (1–42) Aggregation by Increasing Peptide-Peptide Binding Forces
por: Hane, Francis, et al.
Publicado: (2013)

Differential Effects of Endocannabinoids on Amyloid-Beta Aggregation and Toxicity
por: Khavandi, Marzie, et al.
Publicado: (2023)

Effect of Copper and Zinc on the Single Molecule Self-Affinity of Alzheimer’s Amyloid-β Peptides
por: Hane, Francis T., et al.
Publicado: (2016)

Heterocycles in Peptidomimetics and Pseudopeptides: Design and Synthesis (†)
por: Cerminara, Iole, et al.
Publicado: (2012)

Effect of Varying Concentrations of Docosahexaenoic Acid on Amyloid Beta (1–42) Aggregation: An Atomic Force Microscopy Study
por: Lee, Brenda Yasie, et al.
Publicado: (2018)

Evaluating the Antimicrobial and Anti-Hemolytic Activity of Synthesized Pseudopeptide against Leptospiral Species: In Silico and In Vitro Approach
por: Dharmashekar, Chandan, et al.
Publicado: (2023)

New building blocks or dendritic pseudopeptides for metal chelating
por: Ruan, Min, et al.
Publicado: (2016)

Nucleolin mediates the antiangiogenesis effect of the pseudopeptide N6L
por: Birmpas, Charalampos, et al.
Publicado: (2012)

Multivalent cationic pseudopeptide polyplexes as a tool for cancer therapy
por: Diamantopoulou, Zoi, et al.
Publicado: (2017)

Tuning Mechanical Properties of Pseudopeptide Supramolecular Hydrogels by Graphene Doping
por: Giuri, Demetra, et al.
Publicado: (2019)

Suppression of Tumor Growth in Mice by Rationally Designed Pseudopeptide Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase()
por: Jackson, Kenneth W., et al.
Publicado: (2015)

Effect of Surfaces on Amyloid Fibril Formation
por: Moores, Bradley, et al.
Publicado: (2011)

The pseudopeptide HB-19 binds to cell surface nucleolin and inhibits angiogenesis
por: Birmpas, Charalampos, et al.
Publicado: (2012)

Application of the N-Dibenzyl Protective Group in the Preparation of β-Lactam Pseudopeptides
por: Frlan, Rok, et al.
Publicado: (2019)

Modulation of Src Kinase Activity by Selective Substrate Recognition with Pseudopeptidic Cages
por: Tapia, Lucía, et al.
Publicado: (2021)

Continuous Flow Processes as an Enabling Tool for the Synthesis of Constrained Pseudopeptidic Macrocycles
por: Esteve, Ferran, et al.
Publicado: (2022)

Natural Inhibitors of Amyloid Aggregation
por: Tortora, Paolo, et al.
Publicado: (2023)

In Silico Study of the Interactions of Anle138b Isomer, an Inhibitor of Amyloid Aggregation, with Partner Proteins
por: Kondratyev, Maxim S., et al.
Publicado: (2022)

Small molecules to target tau amyloid aggregation
por: Manglano-Artuñedo, Zoe, et al.
Publicado: (2023)

Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease
por: Drolle, Elizabeth, et al.
Publicado: (2017)

Fullerenemalonates inhibit amyloid beta aggregation, in vitro and in silico evaluation
por: Melchor, Martínez-Herrera, et al.
Publicado: (2018)

Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation
por: Wu, Jingjing, et al.
Publicado: (2011)

A Pseudopeptide Polymer Micelle Used for Asymmetric Catalysis of the Aldol Reaction in Water
por: Liu, Keyuan, et al.
Publicado: (2018)

Short Peptides as Inhibitors of Amyloid Aggregation
por: Neddenriep, Bradley, et al.
Publicado: (2011)

ATP-dependent ligases in trypanothione biosynthesis – kinetics of catalysis and inhibition by phosphinic acid pseudopeptides
por: Oza, Sandra L, et al.
Publicado: (2008)

Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis
por: Previti, Santo, et al.
Publicado: (2022)

In Silico Drug Design and Analysis of Dual Amyloid-Beta and Tau Protein-Aggregation Inhibitors for Alzheimer’s Disease Treatment
por: Job, Nisha, et al.
Publicado: (2023)

Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents
por: Pasieka, Anna, et al.
Publicado: (2021)

Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids
por: Horrocks, Mathew H., et al.
Publicado: (2016)

Single molecule sensing of amyloid-β aggregation by confined glass nanopores
por: Yu, Ru-Jia, et al.
Publicado: (2019)

Targeting surface nucleolin with a multivalent pseudopeptide delays development of spontaneous melanoma in RET transgenic mice
por: El Khoury, Diala, et al.
Publicado: (2010)

Unravelling the Supramolecular Driving Forces in the Formation of CO(2)-Responsive Pseudopeptidic Low-Molecular-Weight Hydrogelators
por: Esteve, Ferran, et al.
Publicado: (2022)

Design and synthesis of multi-functional small-molecule based inhibitors of amyloid-β aggregation: Molecular modeling and in vitro evaluation
por: Radwan, Awwad A., et al.
Publicado: (2023)

Recent Progress in Alzheimer’s Disease Research, Part 3: Diagnosis and Treatment
por: Hane, Francis T., et al.
Publicado: (2017)

Development of Designed Site-Directed Pseudopeptide-Peptido-Mimetic Immunogens as Novel Minimal Subunit-Vaccine Candidates for Malaria
por: Lozano, José Manuel, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_mo1i7rmr66f3k87q6k1h74t7c7