Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging

Agglomeration of active pharmaceutical ingredients (API) in tablets can lead to decreased bioavailability in some enabling formulations. In a previous study, we determined that crystalline APIs can be detected as agglomeration in tablets formulated with amorphous acetaminophen tablets. Multiple meth...

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Detalles Bibliográficos
Autores principales: Van Meter, Mariann Inga, Khan, Salah M., Taulbee-Cotton, Brynne V., Dimmitt, Nathan H., Hubbard, Nathan D., Green, Adam M., Webster, Gregory K., McVey, Patrick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865442/
https://www.ncbi.nlm.nih.gov/pubmed/33503894
http://dx.doi.org/10.3390/molecules26030610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865442/
https://www.ncbi.nlm.nih.gov/pubmed/33503894
http://dx.doi.org/10.3390/molecules26030610

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