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Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine

In migraine pain, cannabis has a promising analgesic action, which, however, is associated with side psychotropic effects. To overcome these adverse effects of exogenous cannabinoids, we propose migraine pain relief via activation of the endogenous cannabinoid system (ECS) by inhibiting enzymes degr...

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Detalles Bibliográficos
Autores principales: Della Pietra, Adriana, Giniatullin, Rashid, Savinainen, Juha R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865507/
https://www.ncbi.nlm.nih.gov/pubmed/33530477
http://dx.doi.org/10.3390/ijms22031204