Analyzing Kinase Similarity in Small Molecule and Protein Structural Space to Explore the Limits of Multi-Target Screening

While selective inhibition is one of the key assets for a small molecule drug, many diseases can only be tackled by simultaneous inhibition of several proteins. An example where achieving selectivity is especially challenging are ligands targeting human kinases. This difficulty arises from the high...

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Detalles Bibliográficos
Autores principales: Schmidt, Denis, Scharf, Magdalena M., Sydow, Dominique, Aßmann, Eva, Martí-Solano, Maria, Keul, Marina, Volkamer, Andrea, Kolb, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865522/
https://www.ncbi.nlm.nih.gov/pubmed/33530327
http://dx.doi.org/10.3390/molecules26030629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865522/
https://www.ncbi.nlm.nih.gov/pubmed/33530327
http://dx.doi.org/10.3390/molecules26030629

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