Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways in Human Glioblastoma Cells Independently of Deficiency in TP53 or PTEN Tumor Suppressors

SIMPLE SUMMARY: Glioblastomas (GBMs) are aggressive brain tumors with frequent genetic defects in TP53 and PTEN tumor suppressor genes, which render tumors refractory to standard chemotherapeutics. Natural and synthetic cannabinoids showed antitumor activity in glioma cells and animal glioma models....

Descripción completa

Detalles Bibliográficos
Autores principales: Ellert-Miklaszewska, Aleksandra, Ciechomska, Iwona Anna, Kaminska, Bozena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865605/
https://www.ncbi.nlm.nih.gov/pubmed/33499365
http://dx.doi.org/10.3390/cancers13030419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865605/
https://www.ncbi.nlm.nih.gov/pubmed/33499365
http://dx.doi.org/10.3390/cancers13030419

Ejemplares similares