A Regulatory Loop of FBXW7-MYC-PLK1 Controls Tumorigenesis of MYC-Driven Medulloblastoma

SIMPLE SUMMARY: Group 3 medulloblastoma (MB) is often accompanied by MYC amplification and has a poor prognosis. FBXW7, a critical tumor suppressor in many types of cancer, regulates the proteasome-mediated degradation of oncoproteins including MYC. However, the role of FBXW7 in the tumorigenesis of...

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Detalles Bibliográficos
Autores principales: Wang, Dong, Pierce, Angela, Veo, Bethany, Fosmire, Susan, Danis, Etienne, Donson, Andrew, Venkataraman, Sujatha, Vibhakar, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865656/
https://www.ncbi.nlm.nih.gov/pubmed/33494392
http://dx.doi.org/10.3390/cancers13030387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865656/
https://www.ncbi.nlm.nih.gov/pubmed/33494392
http://dx.doi.org/10.3390/cancers13030387

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