In Silico Inference of Synthetic Cytotoxic Interactions from Paclitaxel Responses

To exploit negatively interacting pairs of cancer somatic mutations in chemotherapy responses or synthetic cytotoxicity (SC), we systematically determined mutational pairs that had significantly lower paclitaxel half maximal inhibitory concentration (IC(50)) values. We evaluated 407 cell lines with...

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Detalles Bibliográficos
Autores principales: Lee, Jeong Hoon, Lee, Kye Hwa, Kim, Ju Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865701/
https://www.ncbi.nlm.nih.gov/pubmed/33499282
http://dx.doi.org/10.3390/ijms22031097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865701/
https://www.ncbi.nlm.nih.gov/pubmed/33499282
http://dx.doi.org/10.3390/ijms22031097

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