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In Silico Inference of Synthetic Cytotoxic Interactions from Paclitaxel Responses
To exploit negatively interacting pairs of cancer somatic mutations in chemotherapy responses or synthetic cytotoxicity (SC), we systematically determined mutational pairs that had significantly lower paclitaxel half maximal inhibitory concentration (IC(50)) values. We evaluated 407 cell lines with...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865701/ https://www.ncbi.nlm.nih.gov/pubmed/33499282 http://dx.doi.org/10.3390/ijms22031097 |