Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells

Huntington disease (HD) is a devastating and presently untreatable neurodegenerative disease characterized by progressively disabling motor and mental manifestations. The sigma-1 receptor (σ1R) is a protein expressed in the central nervous system, whose 3D structure has been recently determined by X...

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Detalles Bibliográficos
Autores principales: Battista, Theo, Pascarella, Gianmarco, Staid, David Sasah, Colotti, Gianni, Rosati, Jessica, Fiorillo, Annarita, Casamassa, Alessia, Vescovi, Angelo Luigi, Giabbai, Barbara, Semrau, Marta Stefania, Fanelli, Sergio, Storici, Paola, Squitieri, Ferdinando, Morea, Veronica, Ilari, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865886/
https://www.ncbi.nlm.nih.gov/pubmed/33525510
http://dx.doi.org/10.3390/ijms22031293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865886/
https://www.ncbi.nlm.nih.gov/pubmed/33525510
http://dx.doi.org/10.3390/ijms22031293

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