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Druggable Transient Pockets in Protein Kinases

Drug discovery using small molecule inhibitors is reaching a stalemate due to low selectivity, adverse off-target effects and inevitable failures in clinical trials. Conventional chemical screening methods may miss potent small molecules because of their use of simple but outdated kits composed of r...

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Detalles Bibliográficos
Autores principales: Umezawa, Koji, Kii, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865889/
https://www.ncbi.nlm.nih.gov/pubmed/33513739
http://dx.doi.org/10.3390/molecules26030651