Mutational Signatures Driven by Epigenetic Determinants Enable the Stratification of Patients with Gastric Cancer for Therapeutic Intervention

SIMPLE SUMMARY: Mutational signatures due to DNA mismatch repair deficiency (dMMR) is common in many cancers. However, the prognostic value of dMMR-associated mutational signatures remains to be assessed. Here, we performed a de novo extraction of mutational signatures in a cohort of 787 patients wi...

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Detalles Bibliográficos
Autores principales: Buttura, Jaqueline Ramalho, Provisor Santos, Monize Nakamoto, Valieris, Renan, Drummond, Rodrigo Duarte, Defelicibus, Alexandre, Lima, João Paulo, Calsavara, Vinicius Fernando, Freitas, Helano Carioca, Cordeiro de Lima, Vladmir C., Fernanda Bartelli, Thais, Wiedner, Marc, Rosales, Rafael, Gollob, Kenneth John, Loizou, Joanna, Dias-Neto, Emmanuel, Nunes, Diana Noronha, da Silva, Israel Tojal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866019/
https://www.ncbi.nlm.nih.gov/pubmed/33513945
http://dx.doi.org/10.3390/cancers13030490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866019/
https://www.ncbi.nlm.nih.gov/pubmed/33513945
http://dx.doi.org/10.3390/cancers13030490

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