A Mathematical Model to Estimate Chemotherapy Concentration at the Tumor-Site and Predict Therapy Response in Colorectal Cancer Patients with Liver Metastases

SIMPLE SUMMARY: It is known that drug transport barriers in the tumor determine drug concentration at the tumor site, causing disparity from the systemic (plasma) drug concentration. However, current clinical standard of care still bases dosage and treatment optimization on the systemic concentratio...

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Detalles Bibliográficos
Autores principales: Anaya, Daniel A., Dogra, Prashant, Wang, Zhihui, Haider, Mintallah, Ehab, Jasmina, Jeong, Daniel K., Ghayouri, Masoumeh, Lauwers, Gregory Y., Thomas, Kerry, Kim, Richard, Butner, Joseph D., Nizzero, Sara, Ramírez, Javier Ruiz, Plodinec, Marija, Sidman, Richard L., Cavenee, Webster K., Pasqualini, Renata, Arap, Wadih, Fleming, Jason B., Cristini, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866038/
https://www.ncbi.nlm.nih.gov/pubmed/33503971
http://dx.doi.org/10.3390/cancers13030444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866038/
https://www.ncbi.nlm.nih.gov/pubmed/33503971
http://dx.doi.org/10.3390/cancers13030444

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