Bicyclic Basic Merbarone Analogues as Antiproliferative Agents

Pyrimido-pyrimidine derivatives have been developed as rigid merbarone analogues. In a previous study, these compounds showed potent antiproliferative activity and efficiently inhibited topoisomerase IIα. To further extend the structure–activity relationships on pyrimido-pyrimidines, a novel series...

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Detalles Bibliográficos
Autores principales: Spallarossa, Andrea, Lusardi, Matteo, Caneva, Chiara, Profumo, Aldo, Rosano, Camillo, Ponassi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866144/
https://www.ncbi.nlm.nih.gov/pubmed/33494519
http://dx.doi.org/10.3390/molecules26030557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866144/
https://www.ncbi.nlm.nih.gov/pubmed/33494519
http://dx.doi.org/10.3390/molecules26030557

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