Cargando…

New 1,2,3-Triazole-Containing Hybrids as Antitumor Candidates: Design, Click Reaction Synthesis, DFT Calculations, and Molecular Docking Study

In an effort to improve and achieve biologically active anticancer agents, a novel series of 1,2,3-triazole-containing hybrids were designed and efficiently synthesized via the Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of substituted-arylazides with alkyne-functionalized pyrazole-[1,2...

Descripción completa

Detalles Bibliográficos
Autores principales:	El Azab, Islam H., El-Sheshtawy, Hamdy S., Bakr, Rania B., Elkanzi, Nadia A. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866392/ https://www.ncbi.nlm.nih.gov/pubmed/33573040 http://dx.doi.org/10.3390/molecules26030708

Ejemplares similares

Facile One-Pot Multicomponent Synthesis of Pyrazolo-Thiazole Substituted Pyridines with Potential Anti-Proliferative Activity: Synthesis, In Vitro and In Silico Studies
por: El Azab, Islam H., et al.
Publicado: (2021)

New thiazole, pyridine and pyrazole derivatives as antioxidant candidates: synthesis, DFT calculations and molecular docking study
por: Kaddouri, Yassine, et al.
Publicado: (2020)

Novel 1,2,3-Triazole-Based Benzothiazole Derivatives: Efficient Synthesis, DFT, Molecular Docking, and ADMET Studies
por: Mirjafary, Zohreh, et al.
Publicado: (2022)

1,2,3-Triazoles of 8-Hydroxyquinoline and HBT: Synthesis and Studies (DNA Binding, Antimicrobial, Molecular Docking, ADME, and DFT)
por: Nehra, Nidhi, et al.
Publicado: (2021)

Molecular Hybridization of Alkaloids Using 1,2,3-Triazole-Based Click Chemistry
por: Buchanan, Devan, et al.
Publicado: (2023)

An Efficient Synthetic Approach Towards Benzo[b]pyrano[2,3-e][1,4]diazepines, and Their Cytotoxic Activity
por: El Azab, Islam H., et al.
Publicado: (2020)

Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-c][1,2,4]triazolo[3,4-f][1,2,4]triazines
por: El Azab, Islam H., et al.
Publicado: (2020)

New 1,2,3-Triazole Scaffold Schiff Bases as Potential Anti-COVID-19: Design, Synthesis, DFT-Molecular Docking, and Cytotoxicity Aspects
por: Said, Musa A., et al.
Publicado: (2021)

Synthesis, anti-inflammatory, bactericidal activities and docking studies of novel 1,2,3-triazoles derived from ibuprofen using click chemistry
por: Angajala, Kishore Kumar, et al.
Publicado: (2016)

Designing Click One-Pot Synthesis and Antidiabetic Studies of 1,2,3-Triazole Derivatives
por: Shafique, Kainat, et al.
Publicado: (2023)

Synthesis of Novel N-Heterocyclic Compounds Containing 1,2,3-Triazole Ring System via Domino, “Click” and RDA Reactions
por: Palkó, Márta, et al.
Publicado: (2019)

New Bicyclic Pyridine-Based Hybrids Linked to the 1,2,3-Triazole Unit: Synthesis via Click Reaction and Evaluation of Neurotropic Activity and Molecular Docking
por: Sirakanyan, Samvel N., et al.
Publicado: (2023)

Click chemistry towards thermally reversible photochromic 4,5-bisthiazolyl-1,2,3-triazoles
por: Zhang, Chenxia, et al.
Publicado: (2019)

Fabrication, DFT Calculation, and Molecular Docking of Two Fe(III) Imine Chelates as Anti-COVID-19 and Pharmaceutical Drug Candidate
por: El-Lateef, Hany M. Abd, et al.
Publicado: (2022)

Cu(i)-catalysed 1,2,3-triazole stitched chalcomer assembly as Pb(ii) and Cu(ii) ion sensor: DFT and docking scrutiny
por: Singh, Riddima, et al.
Publicado: (2023)

Sustainable Construction of Heterocyclic 1,2,3-Triazoles by Strict Click [3+2] Cycloaddition Reactions Between Azides and Alkynes on Copper/Carbon in Water
por: Aflak, Noura, et al.
Publicado: (2019)

1,2,3-Triazoles as Biomimetics in Peptide Science
por: Agouram, Naima, et al.
Publicado: (2021)

Peculiarities of the Spatial and Electronic Structure of 2-Aryl-1,2,3-Triazol-5-Carboxylic Acids and Their Salts on the Basis of Spectral Studies and DFT Calculations
por: Alcolea Palafox, Mauricio, et al.
Publicado: (2023)

Synthesis and Antitumor Activity of Erlotinib Derivatives Linked With 1,2,3-Triazole
por: Deng, Peng, et al.
Publicado: (2022)

Searching potential antiviral candidates for the treatment of the 2019 novel coronavirus based on DFT calculations and molecular docking
por: Sagaama, Abir, et al.
Publicado: (2020)

Efficient and Recoverable Bio-Organic Catalyst Cysteine for Synthesis, Docking Study, and Antifungal Activity of New Bio-Active 3,4-Dihydropyrimidin-2(1H)-ones/thiones Under Microwave Irradiation
por: Elkanzi, Nadia A. A., et al.
Publicado: (2022)

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry
por: Pereira, Daniela, et al.
Publicado: (2021)

Preparation of novel 1,2,3-triazole furocoumarin derivatives via click chemistry and their anti-vitiligo activity
por: Niu, Chao, et al.
Publicado: (2019)

Azidothymidine “Clicked” into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors
por: Berrino, Emanuela, et al.
Publicado: (2020)

Green Design, Synthesis, and Molecular Docking Study of Novel Quinoxaline Derivatives with Insecticidal Potential against Aphis craccivora
por: Alanazi, Mariam Azzam, et al.
Publicado: (2022)

Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR
por: Khattab, Reham R., et al.
Publicado: (2021)

Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives
por: Luo, Han, et al.
Publicado: (2021)

Facile Preparation and Properties of Crosslinked Copolyether Elastomers with 1,2,3‐Triazole and Urethane Subunit via Click Polymerization
por: Zhang, Qian, et al.
Publicado: (2019)

Computational investigations of click-derived 1,2,3-triazoles as keystone ligands for complexation with transition metals: a review
por: Hosseinnejad, Tayebeh, et al.
Publicado: (2018)

1,2,3-Triazoles
por: Rachwal, S., et al.
Publicado: (2008)

‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents
por: Li, Xiang, et al.
Publicado: (2017)

New 1,2,3-Triazole-Appended Bis-pyrazoles: Synthesis, Bioevaluation, and Molecular Docking
por: Danne, Ashruba B., et al.
Publicado: (2021)

Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles
por: Kumar, Aman, et al.
Publicado: (2022)

Efficient One-Pot Synthesis of Indolhydroxy Derivatives Catalyzed by SnCl(2), DFT Calculations and Docking Study
por: Hakmaoui, Yassine, et al.
Publicado: (2022)

The Synthesis and Antitumor Activity of 1,8-Naphthalimide Derivatives Linked 1,2,3-Triazole
por: Xu, Zhong-jie, et al.
Publicado: (2021)

Solvent-free copper-catalyzed click chemistry for the synthesis of N-heterocyclic hybrids based on quinoline and 1,2,3-triazole
por: Tireli, Martina, et al.
Publicado: (2017)

Multicomponent Click Synthesis of New 1,2,3-Triazole Derivatives of Pyrimidine Nucleobases: Promising Acidic Corrosion Inhibitors for Steel
por: González-Olvera, Rodrigo, et al.
Publicado: (2013)

Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry
por: Efthymiou, Tim, et al.
Publicado: (2012)

Correction: Computational investigations of click-derived 1,2,3-triazoles as keystone ligands for complexation with transition metals: a review
por: Hosseinnejad, Tayebeh, et al.
Publicado: (2019)

One-pot nucleophilic substitution–double click reactions of biazides leading to functionalized bis(1,2,3-triazole) derivatives
por: Reissig, Hans-Ulrich, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_efhqjot9194gp3s55lb9vso4ol