Folinate Supplementation Ameliorates Methotrexate Induced Mitochondrial Formate Depletion In Vitro and In Vivo

(1) Background: Antifolate methotrexate (MTX) is the most common disease-modifying antirheumatic drug (DMARD) for treating human rheumatoid arthritis (RA). The mitochondrial-produced formate is essential for folate-mediated one carbon (1C) metabolism. The impacts of MTX on formate homeostasis in unk...

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Detalles Bibliográficos
Autores principales: Sou, Nga-Lai, Huang, Yu-Hsuan, Chen, Der-Yuan, Chen, Yi-Ming, Tang, Feng-Yao, Ko, Hsin-An, Fan, Yi-Hsuan, Lin, Yi-Ying, Wang, Yi-Cheng, Chih, Hui-Ming, Shane, Barry, Huang, Wen-Nan, Chiang, En-Pei Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866403/
https://www.ncbi.nlm.nih.gov/pubmed/33572934
http://dx.doi.org/10.3390/ijms22031350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866403/
https://www.ncbi.nlm.nih.gov/pubmed/33572934
http://dx.doi.org/10.3390/ijms22031350

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