Cargando…

Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases

Under normal conditions, astrocytes perform a number of important physiological functions centered around neuronal support and synapse maintenance. In neurodegenerative diseases including Alzheimer’s, Parkinson’s and prion diseases, astrocytes acquire reactive phenotypes, which are sustained through...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kushwaha, Rajesh, Sinha, Anshuman, Makarava, Natallia, Molesworth, Kara, Baskakov, Ilia V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866439/ https://www.ncbi.nlm.nih.gov/pubmed/33546775 http://dx.doi.org/10.1186/s40478-021-01123-8

Ejemplares similares

Phagocytic Activities of Reactive Microglia and Astrocytes Associated with Prion Diseases Are Dysregulated in Opposite Directions
por: Sinha, Anshuman, et al.
Publicado: (2021)

Reactive astrocytes associated with prion disease impair the blood brain barrier
por: Kushwaha, Rajesh, et al.
Publicado: (2023)

Reactive astrocytes associated with prion disease impair the blood brain barrier
por: Kushwaha, Rajesh, et al.
Publicado: (2023)

The degree of astrocyte activation is predictive of the incubation time to prion disease
por: Makarava, Natallia, et al.
Publicado: (2021)

Region-Specific Response of Astrocytes to Prion Infection
por: Makarava, Natallia, et al.
Publicado: (2019)

Multiple steps of prion strain adaptation to a new host
por: Bocharova, Olga, et al.
Publicado: (2023)

The Evolution of Transmissible Prions: The Role of Deformed Templating
por: Makarava, Natallia, et al.
Publicado: (2013)

Sialylation of the prion protein glycans controls prion replication rate and glycoform ratio
por: Katorcha, Elizaveta, et al.
Publicado: (2015)

Region-Specific Sialylation Pattern of Prion Strains Provides Novel Insight into Prion Neurotropism
por: Makarava, Natallia, et al.
Publicado: (2020)

Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein
por: Makarava, Natallia, et al.
Publicado: (2018)

Correction to: preserving prion strain identity upon replication of prions in vitro using recombinant prion protein
por: Makarava, Natallia, et al.
Publicado: (2018)

Two alternative pathways for generating transmissible prion disease de novo
por: Makarava, Natallia, et al.
Publicado: (2015)

Prion Strain-Specific Structure and Pathology: A View from the Perspective of Glycobiology
por: Baskakov, Ilia V., et al.
Publicado: (2018)

Sialylation of Prion Protein Controls the Rate of Prion Amplification, the Cross-Species Barrier, the Ratio of PrP(Sc) Glycoform and Prion Infectivity
por: Katorcha, Elizaveta, et al.
Publicado: (2014)

Prion replication environment defines the fate of prion strain adaptation
por: Katorcha, Elizaveta, et al.
Publicado: (2018)

Genesis of Mammalian Prions: From Non-infectious Amyloid Fibrils to a Transmissible Prion Disease
por: Makarava, Natallia, et al.
Publicado: (2011)

Fast and ultrasensitive method for quantitating prion infectivity titer
por: Makarava, Natallia, et al.
Publicado: (2012)

Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults
por: Makarava, Natallia, et al.
Publicado: (2023)

Reversible off and on switching of prion infectivity via removing and reinstalling prion sialylation
por: Katorcha, Elizaveta, et al.
Publicado: (2016)

Alzheimer’s disease-associated β-amyloid does not protect against herpes simplex virus 1 infection in the mouse brain
por: Bocharova, Olga, et al.
Publicado: (2021)

On the reactive states of astrocytes in prion diseases
por: Baskakov, Ilia V.
Publicado: (2021)

Inflammatory response of microglia to prions is controlled by sialylation of PrP(Sc)
por: Srivastava, Saurabh, et al.
Publicado: (2018)

Recombinant prion protein induces a new transmissible prion disease in wild-type animals
por: Makarava, Natallia, et al.
Publicado: (2010)

Genesis of tramsmissible protein states via deformed templating
por: Makarava, Natallia, et al.
Publicado: (2012)

Deficiency in ST6GAL1, one of the two α2,6-sialyltransferases, has only a minor effect on the pathogenesis of prion disease
por: Makarava, Natallia, et al.
Publicado: (2022)

Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy
por: Katorcha, Elizaveta, et al.
Publicado: (2017)

Molecular Structure of Amyloid Fibrils Controls the Relationship between Fibrillar Size and Toxicity
por: Lee, Young Jin, et al.
Publicado: (2011)

Aβ plaques do not protect against HSV‐1 infection in a mouse model of familial Alzheimer's disease, and HSV‐1 does not induce Aβ pathology in a model of late onset Alzheimer's disease
por: Bocharova, Olga V., et al.
Publicado: (2022)

Strain-dependent profile of misfolded prion protein aggregates
por: Morales, Rodrigo, et al.
Publicado: (2016)

Loss of Cellular Sialidases Does Not Affect the Sialylation Status of the Prion Protein but Increases the Amounts of Its Proteolytic Fragment C1
por: Katorcha, Elizaveta, et al.
Publicado: (2015)

Contrasting Effects of Two Lipid Cofactors of Prion Replication on the Conformation of the Prion Protein
por: Srivastava, Saurabh, et al.
Publicado: (2015)

PrP charge structure encodes interdomain interactions
por: Martínez, Javier, et al.
Publicado: (2015)

Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact
por: Victoria, Guiliana Soraya, et al.
Publicado: (2016)

Multifaceted Role of Sialylation in Prion Diseases
por: Baskakov, Ilia V., et al.
Publicado: (2016)

Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons
por: Sharma, Shreya Das, et al.
Publicado: (2023)

Highly Efficient Protein Misfolding Cyclic Amplification
por: Gonzalez-Montalban, Nuria, et al.
Publicado: (2011)

Fibrinogen Mitigates Prion-Mediated Platelet Activation and Neuronal Cell Toxicity
por: Gautam, Deepa, et al.
Publicado: (2022)

Unraveling prion structures and biological functions
por: Ter-Avanesyan, Michael, et al.
Publicado: (2005)

Gingerol prevents prion protein-mediated neuronal toxicity by regulating HIF prolyl hydroxylase 2 and prion protein
por: PARK, YANG-GYU, et al.
Publicado: (2014)

Enhanced phosphorylation of PERK in primary cultured neurons as an autonomous neuronal response to prion infection
por: Tanaka, Misaki, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_di6pkl8n30fgcqn6r3fi5u8ffv