Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses

The synthesis of α-fluorinated methyl ketones has always been challenging. New methods based on the homologation chemistry via nucleophilic halocarbenoid transfer, carried out recently in our labs, allowed us to design and synthesize a target-directed dipeptidyl α,α-difluoromethyl ketone (DFMK) 8 as...

Descripción completa

Detalles Bibliográficos
Autores principales: Citarella, Andrea, Gentile, Davide, Rescifina, Antonio, Piperno, Anna, Mognetti, Barbara, Gribaudo, Giorgio, Sciortino, Maria Teresa, Holzer, Wolfgang, Pace, Vittorio, Micale, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866854/
https://www.ncbi.nlm.nih.gov/pubmed/33573283
http://dx.doi.org/10.3390/ijms22031398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866854/
https://www.ncbi.nlm.nih.gov/pubmed/33573283
http://dx.doi.org/10.3390/ijms22031398

Ejemplares similares