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Advances and Obstacles in Homology-Mediated Gene Editing of Hematopoietic Stem Cells

Homology-directed gene editing of hematopoietic stem and progenitor cells (HSPCs) is a promising strategy for the treatment of inherited blood disorders, obviating many of the limitations associated with viral vector-mediated gene therapies. The use of CRISPR/Cas9 or other programmable nucleases and...

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Detalles Bibliográficos
Autores principales:	Salisbury-Ruf, Christi T., Larochelle, Andre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867106/ https://www.ncbi.nlm.nih.gov/pubmed/33535527 http://dx.doi.org/10.3390/jcm10030513

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