Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484

Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, is the main physiological inhibitor of plasminogen activators. By interacting with matrix components, including vitronectin (Vn), PAI-1 plays a regulatory role in tissue remodeling, cell migration, and intracellul...

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Detalles Bibliográficos
Autores principales: Sillen, Machteld, Miyata, Toshio, Vaughan, Douglas E., Strelkov, Sergei V., Declerck, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867230/
https://www.ncbi.nlm.nih.gov/pubmed/33540702
http://dx.doi.org/10.3390/ijms22031482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867230/
https://www.ncbi.nlm.nih.gov/pubmed/33540702
http://dx.doi.org/10.3390/ijms22031482

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