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Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484
Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, is the main physiological inhibitor of plasminogen activators. By interacting with matrix components, including vitronectin (Vn), PAI-1 plays a regulatory role in tissue remodeling, cell migration, and intracellul...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867230/ https://www.ncbi.nlm.nih.gov/pubmed/33540702 http://dx.doi.org/10.3390/ijms22031482 |