Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction

SIMPLE SUMMARY: Renal cell carcinoma (RCC) is the eighth leading malignancy in the world, accounting for 4% of all cancers with poor outcome when metastatic. Protein kinases are highly druggable proteins, which are often aberrantly activated in cancers. The aim of our study was to identify candidate...

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Detalles Bibliográficos
Autores principales: Giacosa, Sofia, Pillet, Catherine, Séraudie, Irinka, Guyon, Laurent, Wallez, Yann, Roelants, Caroline, Battail, Christophe, Evrard, Bertrand, Chalmel, Frédéric, Barette, Caroline, Soleilhac, Emmanuelle, Fauvarque, Marie-Odile, Franquet, Quentin, Sarrazin, Clément, Peilleron, Nicolas, Fiard, Gaëlle, Long, Jean-Alexandre, Descotes, Jean-Luc, Cochet, Claude, Filhol, Odile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867364/
https://www.ncbi.nlm.nih.gov/pubmed/33540838
http://dx.doi.org/10.3390/cancers13030576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867364/
https://www.ncbi.nlm.nih.gov/pubmed/33540838
http://dx.doi.org/10.3390/cancers13030576

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