Stochastic asymmetric repartition of lytic machinery in dividing CD8(+) T cells generates heterogeneous killing behavior

Cytotoxic immune cells are endowed with a high degree of heterogeneity in their lytic function, but how this heterogeneity is generated is still an open question. We therefore investigated if human CD8(+) T cells could segregate their lytic components during telophase, using imaging flow cytometry,...

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Detalles Bibliográficos
Autores principales: Lafouresse, Fanny, Jugele, Romain, Müller, Sabina, Doineau, Marine, Duplan-Eche, Valérie, Espinosa, Eric, Puisségur, Marie-Pierre, Gadat, Sébastien, Valitutti, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867409/
https://www.ncbi.nlm.nih.gov/pubmed/33427199
http://dx.doi.org/10.7554/eLife.62691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867409/
https://www.ncbi.nlm.nih.gov/pubmed/33427199
http://dx.doi.org/10.7554/eLife.62691

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