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The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin
Overnutrition causes hyperactivation of mTORC1-dependent negative feedback loops leading to the downregulation of insulin signaling and development of insulin resistance. In osteoblasts (OBs), insulin signaling plays a crucial role in the control of systemic glucose homeostasis. We utilized mice wit...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868369/ https://www.ncbi.nlm.nih.gov/pubmed/33551450 http://dx.doi.org/10.1038/s41413-020-00123-z |