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miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse Stria Vascularis

Pathogenic mutations in the non-syndromic hearing loss and deafness 1 (DFNB1) locus are the primary cause of monogenic inheritance for prelingual hearing loss. To unravel molecular pathways involved in etiopathology and look for early degeneration biomarkers, we used a system biology approach to ana...

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Detalles Bibliográficos
Autores principales: Gentile, Giulia, Paciello, Fabiola, Zorzi, Veronica, Spampinato, Antonio Gianmaria, Guarnaccia, Maria, Crispino, Giulia, Tettey-Matey, Abraham, Scavizzi, Ferdinando, Raspa, Marcello, Fetoni, Anna Rita, Cavallaro, Sebastiano, Mammano, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868390/
https://www.ncbi.nlm.nih.gov/pubmed/33569381
http://dx.doi.org/10.3389/fcell.2020.616878