Cargando…

miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse Stria Vascularis

Pathogenic mutations in the non-syndromic hearing loss and deafness 1 (DFNB1) locus are the primary cause of monogenic inheritance for prelingual hearing loss. To unravel molecular pathways involved in etiopathology and look for early degeneration biomarkers, we used a system biology approach to ana...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gentile, Giulia, Paciello, Fabiola, Zorzi, Veronica, Spampinato, Antonio Gianmaria, Guarnaccia, Maria, Crispino, Giulia, Tettey-Matey, Abraham, Scavizzi, Ferdinando, Raspa, Marcello, Fetoni, Anna Rita, Cavallaro, Sebastiano, Mammano, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868390/ https://www.ncbi.nlm.nih.gov/pubmed/33569381 http://dx.doi.org/10.3389/fcell.2020.616878

Ejemplares similares

Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss
por: Paciello, Fabiola, et al.
Publicado: (2022)

Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway
por: Fetoni, Anna Rita, et al.
Publicado: (2018)

Tissue-Resident Macrophages in the Stria Vascularis
por: Ito, Taku, et al.
Publicado: (2022)

Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?
por: Liu, Huizhan, et al.
Publicado: (2016)

Transcript Profiles of Stria Vascularis in Models of Waardenburg Syndrome
por: Chen, Linjun, et al.
Publicado: (2020)

Hearing Function, Degeneration, and Disease: Spotlight on the Stria Vascularis
por: Thulasiram, Matsya R, et al.
Publicado: (2022)

Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis
por: Zhang, Na, et al.
Publicado: (2020)

Identification of Potential Meniere's Disease Targets in the Adult Stria Vascularis
por: Gu, Shoujun, et al.
Publicado: (2021)

Development of the stria vascularis in the common marmoset, a primate model
por: Hosoya, Makoto, et al.
Publicado: (2022)

Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders
por: Xu, Liang, et al.
Publicado: (2017)

Epithelial Cell Stretching and Luminal Acidification Lead to a Retarded Development of Stria Vascularis and Deafness in Mice Lacking Pendrin
por: Kim, Hyoung-Mi, et al.
Publicado: (2011)

Connexin Hemichannel Activation by S-Nitrosoglutathione Synergizes Strongly with Photodynamic Therapy Potentiating Anti-Tumor Bystander Killing
por: Nardin, Chiara, et al.
Publicado: (2021)

Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function
por: Zorzi, Veronica, et al.
Publicado: (2017)

Single-cell RNA-sequencing of stria vascularis cells in the adult Slc26a4(-/-) mouse
por: Koh, Jin-Young, et al.
Publicado: (2023)

Estimation of Volume of Stria Vascularis and the Length of Its Capillaries in the Human Cochlea
por: Poorna Pillutla, Sree Vani, et al.
Publicado: (2019)

Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model
por: Jabba, Sairam V, et al.
Publicado: (2006)

Role of the Stria Vascularis in the Pathogenesis of Sensorineural Hearing Loss: A Narrative Review
por: Yu, Wenting, et al.
Publicado: (2021)

The ultrastructure of a stria vascularis in the auditory organ of the cuban crocodile (Crocodylus rhombifer)
por: Li, Hao, et al.
Publicado: (2023)

Neutrophils infiltrate into the spiral ligament but not the stria vascularis in the cochlea during lipopolysaccharide-induced inflammation
por: Bae, Seong Hoon, et al.
Publicado: (2021)

D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
por: Peng, Zhe, et al.
Publicado: (2023)

Single Cell and Single Nucleus RNA-Seq Reveal Cellular Heterogeneity and Homeostatic Regulatory Networks in Adult Mouse Stria Vascularis
por: Korrapati, Soumya, et al.
Publicado: (2019)

Attenuating Cardiac Pulsations within the Cochlea: Structure and Function of Tortuous Vessels Feeding Stria Vascularis
por: Carraro, Mattia, et al.
Publicado: (2013)

Characterization of rare spindle and root cell transcriptional profiles in the stria vascularis of the adult mouse cochlea
por: Gu, Shoujun, et al.
Publicado: (2020)

Transcriptomic Analysis Reveals an Altered Hcy Metabolism in the Stria Vascularis of the Pendred Syndrome Mouse Model
por: Xue, Wenyue, et al.
Publicado: (2021)

Development of the stria vascularis and potassium regulation in the human fetal cochlea: Insights into hereditary sensorineural hearing loss
por: Locher, Heiko, et al.
Publicado: (2015)

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors
por: Crispino, Giulia, et al.
Publicado: (2017)

Betahistine Exerts a Dose-Dependent Effect on Cochlear Stria Vascularis Blood Flow in Guinea Pigs In Vivo
por: Ihler, Fritz, et al.
Publicado: (2012)

The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion
por: Miyazaki, Hiromitsu, et al.
Publicado: (2016)

Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets
por: Taukulis, Ian A., et al.
Publicado: (2021)

Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea
por: Johnson, Stuart L., et al.
Publicado: (2017)

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss
por: Trpchevska, Natalia, et al.
Publicado: (2022)

Transgenic Tg(Kcnj10-ZsGreen) Fluorescent Reporter Mice Allow Visualization of Intermediate Cells in the Stria Vascularis
por: Strepay, Dillon, et al.
Publicado: (2023)

RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis
por: Dufek, Brianna, et al.
Publicado: (2020)

Pericytes of Stria Vascularis Are Targets of Cisplatin-Induced Ototoxicity: New Insights into the Molecular Mechanisms Involved in Blood-Labyrinth Barrier Breakdown
por: Anfuso, Carmelina Daniela, et al.
Publicado: (2022)

Age-associated variation in the expression and function of TMEM16A calcium-activated chloride channels in the cochlear stria vascularis of guinea pigs
por: Zhou, Ying, et al.
Publicado: (2019)

Age-related hearing loss was accelerated by apoptosis of spiral ganglion and stria vascularis cells in ApoE KO mice with hyperglycemia and hyperlipidemia
por: Nguyen, Phuong Thi Thanh, et al.
Publicado: (2022)

Development of a Serum-Free Culture Method for Endothelial Cells of the Stria Vascularis and Their Pro-inflammatory Secretome Changes Induced by Oxidative Stress
por: Yi, Ying, et al.
Publicado: (2023)

A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice
por: Kuang, Yuanyuan, et al.
Publicado: (2020)

The p.Cys169Tyr variant of connexin 26 is not a polymorphism
por: Zonta, Francesco, et al.
Publicado: (2015)

The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice
por: Schütz, Melanie, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_fauhn344ldihoc6pdh6uu9e530