Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12

Post-SELEX modification of DNA aptamers is an established strategy to improve their affinity or inhibitory characteristics. In this study, we examined the possibility of increasing the recognition interface between the thrombin-binding aptamer HD1 (TBA) and thrombin by adding a chemically modified s...

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Detalles Bibliográficos
Autores principales: Smirnov, Igor, Kolganova, Natalia, Troisi, Romualdo, Sica, Filomena, Timofeev, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868722/
https://www.ncbi.nlm.nih.gov/pubmed/33614235
http://dx.doi.org/10.1016/j.omtn.2021.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868722/
https://www.ncbi.nlm.nih.gov/pubmed/33614235
http://dx.doi.org/10.1016/j.omtn.2021.01.004

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