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Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12
Post-SELEX modification of DNA aptamers is an established strategy to improve their affinity or inhibitory characteristics. In this study, we examined the possibility of increasing the recognition interface between the thrombin-binding aptamer HD1 (TBA) and thrombin by adding a chemically modified s...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868722/ https://www.ncbi.nlm.nih.gov/pubmed/33614235 http://dx.doi.org/10.1016/j.omtn.2021.01.004 |