Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions

[Image: see text] Ion channels are proteins which form gated nanopores in biological membranes. Many channels exhibit hydrophobic gating, whereby functional closure of a pore occurs by local dewetting. The pentameric ligand gated ion channels (pLGICs) provide a biologically important example of hydr...

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Detalles Bibliográficos
Autores principales: Rao, Shanlin, Klesse, Gianni, Lynch, Charlotte I., Tucker, Stephen J., Sansom, Mark S. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869105/
https://www.ncbi.nlm.nih.gov/pubmed/33439645
http://dx.doi.org/10.1021/acs.jpcb.0c09285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869105/
https://www.ncbi.nlm.nih.gov/pubmed/33439645
http://dx.doi.org/10.1021/acs.jpcb.0c09285

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