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Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions

[Image: see text] Ion channels are proteins which form gated nanopores in biological membranes. Many channels exhibit hydrophobic gating, whereby functional closure of a pore occurs by local dewetting. The pentameric ligand gated ion channels (pLGICs) provide a biologically important example of hydr...

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Detalles Bibliográficos
Autores principales:	Rao, Shanlin, Klesse, Gianni, Lynch, Charlotte I., Tucker, Stephen J., Sansom, Mark S. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869105/ https://www.ncbi.nlm.nih.gov/pubmed/33439645 http://dx.doi.org/10.1021/acs.jpcb.0c09285

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