DDB2 regulates DNA replication through PCNA-independent degradation of CDT2

BACKGROUND: Targeting ubiquitin-dependent proteolysis is one of the strategies in cancer therapy. CRL(CDT2) and CRL(DDB2) are two key E3 ubiquitin ligases involved in DNA replication and DNA damage repair. But CDT2 and DDB2 are opposite prognostic factors in kinds of cancers, and the underlining mec...

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Detalles Bibliográficos
Autores principales: Wu, Xiaojun, Yu, Min, Zhang, Zhuxia, Leng, Feng, Ma, Yue, Xie, Ni, Lu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869461/
https://www.ncbi.nlm.nih.gov/pubmed/33557942
http://dx.doi.org/10.1186/s13578-021-00540-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869461/
https://www.ncbi.nlm.nih.gov/pubmed/33557942
http://dx.doi.org/10.1186/s13578-021-00540-5

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