Integrin αIIbβ3 outside-in signaling activates human platelets through serine 24 phosphorylation of Disabled-2

BACKGROUND: Bidirectional integrin αIIbβ3 signaling is essential for platelet activation. The platelet adaptor protein Disabled-2 (Dab2) is a key regulator of integrin signaling and is phosphorylated at serine 24 in eukaryotic cells. However, the mechanistic insight and function of Dab2-serine 24 ph...

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Detalles Bibliográficos
Autores principales: Tsai, Hui-Ju, Cheng, Ju-Chien, Kao, Man-Leng, Chiu, Hung-Pin, Chiang, Yi-Hsuan, Chen, Ding-Ping, Rau, Kun-Ming, Liao, Hsiang-Ruei, Tseng, Ching-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869483/
https://www.ncbi.nlm.nih.gov/pubmed/33557943
http://dx.doi.org/10.1186/s13578-021-00532-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869483/
https://www.ncbi.nlm.nih.gov/pubmed/33557943
http://dx.doi.org/10.1186/s13578-021-00532-5

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